The 37-year-old man was pronounced dead at the scene of the crash in Plashet Road near the junction with Lucas Avenue in Newham.
Emergency services were called to the scene shortly after 5.40pm on Saturday.
A Scotland Yard statement said: “Officers attended the location along with London Ambulance Service, where they found a male motorcyclist who had collided with a lamppost. The 37-year-old man was pronounced dead at the scene.”
Enquiries into the incident are ongoing.
His family have been informed though there has not been formal identification yet.